ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1
نویسندگان
چکیده
منابع مشابه
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.
The genetic syndrome Fanconi anemia (FA) is characterized by aplastic anemia, cancer predisposition and hypersensitivity to DNA interstrand crosslinks (ICLs). FA proteins (FANCs) are thought to work in pathway(s) essential for dealing with crosslinked DNA. FANCs interact with other proteins involved in both DNA repair and S-phase checkpoint such as BRCA1, ATM and the RAD50/MRE11/NBS1 (RMN) comp...
متن کاملWRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.
Checkpoints are cellular surveillance and signaling pathways that coordinate the response to DNA damage and replicative stress. Consequently, failure of cellular checkpoints increases susceptibility to DNA damage and can lead to profound genome instability. This study examines the role of a human RECQ helicase, WRN, in checkpoint activation in response to DNA damage. Mutations in WRN lead to ge...
متن کاملCarcinogenicity of hexavalent chromium.
Hexavalent chromium (Cr(VI)), a commonly used industrial metal, is a well known human lung carcinogen. Epidemiology and animal studies suggest that the particulate Cr(VI) compounds, specifically the water insoluble compounds, are the more potent carcinogens; however, the carcinogenic mechanism remains unknown. Here we summarize recent Cr(VI)-induced human tumour, in vivo, cell culture and in vi...
متن کاملDissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint.
Replication protein A (RPA) is a trimeric single-stranded DNA-binding protein complex involved in DNA replication, repair, and recombination. DNA damage induces phosphorylation of the RPA p34 subunit, and it has been speculated that this phosphorylation could contribute to the regulation of the DNA damage-induced S-phase checkpoint. To further examine this potential relationship, human cell lin...
متن کاملReplication Protein A from the S-Phase Checkpoint Dissociation of Radiation-induced Phosphorylation of Updated Version
that this phosphorylation event may contribute to the inhibition of DNA replication activity (12, 13). These studies, in conjunction with the observation that cell lines derived from AT patients lack the irradiation-induced S-phase arrest (i.e., exhibit RDS; Refs. 22 and 23) and are deficient in IR-induced RPA phosphorylation (13, 14), sug gested that RPA phosphorylation may play a functional r...
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ژورنال
عنوان ژورنال: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
سال: 2006
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2006.06.007